Functional neurological symptoms, psychological aspects, life events and their interaction in patients with multiple sclerosis

Functional neurological symptoms, psychological aspects, life events and their interaction in patients with multiple sclerosis - FNS-MS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00022105

Enrollment

210

Registered

2020-07-01

Start date

2020-08-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G35 F44

Interventions

Group 1: Newly admitted MS patients receive a set of questionnaires consisting of the questionnaire recording the neurological symptoms (anamnesis sheet), SF-36 (Short-Form-36 Health Survey) assessing

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: A MS diagnosis based on McDonald criteria; duration of stay at the Kliniken Schmieder of at least 3 weeks

Exclusion criteria

Exclusion criteria: motor or cognitive deficits as a consequence/manifestation of another neurological disorder; motor or cognitive deficits that make it impossible to fill out the questionnaires; one or more disorder from the schizophrenia spectrum disorders

Design outcomes

Primary

Measure	Time frame
The main objective of the study (primary outcome) is to assess the prevalence of FNS in patients with MS. FNS are assessed with organicity rating.	—

Secondary

Measure	Time frame
Further study objectives (secondary outcome): 1. Assess factors that promote FNS and their associations with FNS in patients with MS 2. Identification of the appropriate diagnostic approach of comorbid FNS in MS by evaluating and integrating the above mentioned findings The FNS promoting factors are measured with the following instruments: - Life events in the past year (Life Experiences Survey, LES) - Depression and anxiety symptoms (Hospital Anxiety and Depression Scale - German Version, HADS-D) - Alexithymia (Toronto Alexithymia Scale 26, TAS-26) - Emotion regulation strategies (Emotion Regulation Questionnaire, ERQ) - Dissociation (Dissociative Experience Scale, DES) - Traumatic life events (Life Events Checklist, LEC-5) - Post-traumatic stress disorder (PTSD Checklist for DSM-5, PCL-5) - Adverse experiences in childhood and adolescence (Childhood Trauma Questionnaire, CTQ) - Cortisol response (Socially Evaluated Cold Pressor Test, SECPT) - Interoception (Mental Tracking Method) The variables or measurements described above take place at the beginning of the stay.	—

Measure

Time frame

Further study objectives (secondary outcome): 1. Assess factors that promote FNS and their associations with FNS in patients with MS 2. Identification of the appropriate diagnostic approach of comorbid FNS in MS by evaluating and integrating the above mentioned findings The FNS promoting factors are measured with the following instruments: - Life events in the past year (Life Experiences Survey, LES) - Depression and anxiety symptoms (Hospital Anxiety and Depression Scale - German Version, HADS-D) - Alexithymia (Toronto Alexithymia Scale 26, TAS-26) - Emotion regulation strategies (Emotion Regulation Questionnaire, ERQ) - Dissociation (Dissociative Experience Scale, DES) - Traumatic life events (Life Events Checklist, LEC-5) - Post-traumatic stress disorder (PTSD Checklist for DSM-5, PCL-5) - Adverse experiences in childhood and adolescence (Childhood Trauma Questionnaire, CTQ) - Cortisol response (Socially Evaluated Cold Pressor Test, SECPT) - Interoception (Mental Tracking Method) The variables or measurements described above take place at the beginning of the stay.

—

Countries

Germany

Contacts

Public ContactKateryna Piliavska

Lurija Institut

k.piliavska@kliniken-schmieder.de+4975319863583

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026