alcohol use disorder
Conditions
Interventions
Group 1: Subjects with alcohol use disorder:
Investigation of reward sensitivity based on the saccade velocity towards a reward-associated visual cue
Group 2: Healthy control subjects:
Investigation o
Sponsors
Zentralinstitut für Seelische Gesundheit Mannheim
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Subjects with alcohol use disorder: • Men and women between the ages of 18 and 65 • Fulfillment of at least 2 and maximum of 5 of the criteria for an alcohol use disorder ("Alcohol Use Disorder") according to DSM-V, corresponding to a mild to moderate alcohol consumption disorder • Adequate ability to communicate with the examiner to answer questions verbally and in writing • Ability to consent after detailed written clarification ("Fully Informed Consent") • Normal or correctable (with contact lenses) poor eyesight • abstinence from alcohol on Test day Healthy subjects in the control group: • Men and women between the ages of 18 and 65 • Alcohol consumption on a maximum of 5 days a week, a maximum of 12 g each alcohol per day for women (equivalent to 0.3 l beer; 0.125 l wine) and 24 g alcohol per day for men (corresponding to 0.6 l beer; 0.25 l wine) • Adequate ability to communicate with the examiner to answer questions verbally and in writing • Ability to consent after detailed written clarification ("Fully Informed Consent") • Normal or correctable (with contact lenses) poor eyesight • abstinence from alcohol on test day
Exclusion criteria
Exclusion criteria: Subjects with alcohol use disorder: • Withdrawal of the declaration of consent • Alcohol consumption on the day of the examination (breath alcohol concentration> 0.3 ‰) • Axis I disorder DSM 5 (except alcohol consumption disorder and Nicotine use disorder) within the past 12 months • Pharmacotherapy with psychoactive substances within the past 14 days (except for stable doses of non-dopamine-active antidepressants and neuroleptics) • Current drug abuse (THC, amphetamine, opiates, Benzodiazepines, barbiturates and cocaine) • Not able to communicate with the examiner • wearing glasses (without the possibility to wear contact lenses) • Parkinson's disease • History of withdrawal delirium or seizures • Withdrawal symptoms determined via Clinical Institute Withdrawal Assessment for Alcohol Score (Score> 4) Healthy subjects in the control group: • Withdrawal of the declaration of consent • Fulfillment of> = 1 "Alcohol Use Disorder" criteria according to DSM-V • Alcohol consumption on the day of the examination (breath alcohol concentration> 0.3 ‰) • Axis I disorder DSM 5 (except alcohol use disorder and Nicotine use disorder) within the past 12 months • Pharmacotherapy with psychoactive substances within the past 14 days (except for stable doses of non-dopamine-active antidepressants and neuroleptics) • Current drug abuse (THC, amphetamine, opiates, Benzodiazepines, barbiturates and cocaine) • Not able to communicate with the examiner • wearing glasses (without the possibility to wear contact lenses) • Parkinson's disease • History of withdrawal delirium or seizures • Withdrawal symptoms determined via Clinical Institute Withdrawal Assessment for Alcohol Score (Score> 4)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of response times to different reward stimuli between alcohol consumption disorder and control group | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the parameters - pupil size in the anticipation phase; - pupil size in the reward phase; - blink rate between alcohol consumption and control groups | — |
Countries
Germany
Contacts
Public ContactPatrick Bach
Zentralinstitut für Seelische Gesundheit Mannheim
Outcome results
None listed