The analgesic effectiveness of the distal sciatic nerve block and the occurrence of rebound pain after foot and ankle surgery- an observational study.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00021766

Enrollment

110

Registered

2020-05-18

Start date

2020-05-21

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain

Interventions

Group 1: Distal sciatic (popliteal) nerve block in combination with general anesthesia The decision to distal blockage of the sciatic nerve for postoperative pain therapy is made by the anesthetist a

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Elective surgery on the foot or ankle in general anesthesia with moderate to severe postoperative pain to be expected Patients >/= 18 years Ability to consent and willingness to participate in the study A written declaration of consent is available Sufficient knowledge of German

Exclusion criteria

Exclusion criteria: Patients <18 years or unable to give consent Emergency interventions Refusal to participate in the study

Design outcomes

Primary

Measure	Time frame
Integrated pain scores (IPS) within the first 24 hours: calculated from pain scores and morphine equivalents (MEQ), pain level taking into account any higher MEQ requirements. 'Rebound pain', defined as a significantly increased IPS value after the subjectively reported decay of regional anesthesia, which can be measured over a certain period in comparison to the control group.	—

Secondary

Measure	Time frame
- Morphine equivalent consumption (MEQ consumption in milligrams) assuming equianalgesia (comparable pain scores) within the first 24 hours - Pain intensity on NRS from 0-10 at rest and during exercise every 3 hours within the first 24 hours (NRS-AUC), pain quality on NRS from 0-10) - MEQ PACU (recovery room) - Time to first analgesic request - Peak NRS pain score 0-24 hours, time of peak NRS, number of patients reaching peak NRS 7 - Possibly. Subgroup analysis in high-risk patients (IPS from +100 to +200), severe pain and high morphine consumption) with regard to the occurrence of 'rebound pain' - Opioid-related side-effects (Opioid-related Symptom Distress Scale, OR-SDS) 0-24 hours - Validation of the German translation of the Quality of recovery-15 (QoR-15) questionnaire 0-24 hours - Patient satisfaction (NRS), postoperative recovery (QoR-15, GSR), incidence of PONV, sleep quality 0-24 hours - Pain intensity at rest and during movement (NRS) retrospectively after 1 week - frequency of complications (nerve damage, allergic reactions, systemic local anesthetic reactions, surgical complications) - Which psychosocial factors are predestining for the occurrence of 'rebound pain'? - Pain expectations (NRS) preoperative assessment - Pain disasterization (PCS), preoperative survey - Optimism (LOT-R), preoperative survey - Surgical Fear Questionnaire (SFQ), preoperative assessment - General Self-Efficacy Scale (GSES), preoperative recording - Validation of the SFQ (a total of 300 patients are required to validate the SFQ, therefore a subsequent amendment, recruitment of patients regardless of the surgical procedure) - Chronified postoperative pain (CPS) follow-up after three months (questionnaire survey), what is the relationship between 'rebound pain' and chronified postoperative pain? - Course - chronic postoperative pain: follow-up after 3 months (PDI, NRS, Quality of Life)	—

Measure

Time frame

- Morphine equivalent consumption (MEQ consumption in milligrams) assuming equianalgesia (comparable pain scores) within the first 24 hours - Pain intensity on NRS from 0-10 at rest and during exercise every 3 hours within the first 24 hours (NRS-AUC), pain quality on NRS from 0-10) - MEQ PACU (recovery room) - Time to first analgesic request - Peak NRS pain score 0-24 hours, time of peak NRS, number of patients reaching peak NRS 7 - Possibly. Subgroup analysis in high-risk patients (IPS from +100 to +200), severe pain and high morphine consumption) with regard to the occurrence of 'rebound pain' - Opioid-related side-effects (Opioid-related Symptom Distress Scale, OR-SDS) 0-24 hours - Validation of the German translation of the Quality of recovery-15 (QoR-15) questionnaire 0-24 hours - Patient satisfaction (NRS), postoperative recovery (QoR-15, GSR), incidence of PONV, sleep quality 0-24 hours - Pain intensity at rest and during movement (NRS) retrospectively after 1 week - frequency of complications (nerve damage, allergic reactions, systemic local anesthetic reactions, surgical complications) - Which psychosocial factors are predestining for the occurrence of 'rebound pain'? - Pain expectations (NRS) preoperative assessment - Pain disasterization (PCS), preoperative survey - Optimism (LOT-R), preoperative survey - Surgical Fear Questionnaire (SFQ), preoperative assessment - General Self-Efficacy Scale (GSES), preoperative recording - Validation of the SFQ (a total of 300 patients are required to validate the SFQ, therefore a subsequent amendment, recruitment of patients regardless of the surgical procedure) - Chronified postoperative pain (CPS) follow-up after three months (questionnaire survey), what is the relationship between 'rebound pain' and chronified postoperative pain? - Course - chronic postoperative pain: follow-up after 3 months (PDI, NRS, Quality of Life)

—

Countries

Germany

Contacts

Public ContactThomas Wiesmann

Philipps Universität Marburg Universitätsklinikum Marburg Klinik für Anästhesie und Intensivtherapie

wiesmann@med.uni-marburg.de+49 6421 58 69362

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 9, 2026