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Laparoscopic liver resection (LLR) with low central venous pressure (CVP) by anaesthesiological CVP reduction vs. LLR without CVP reduction in elective hepatic resection – A Randomized Controlled Trial

Laparoscopic liver resection (LLR) with low central venous pressure (CVP) by anaesthesiological CVP reduction vs. LLR without CVP reduction in elective hepatic resection – A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00021748
Enrollment
120
Registered
2020-06-17
Start date
2020-07-09
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with elective laparoscopic liver resection C22 C78.7 D13.4 C22.1

Interventions

Group 1: Group A (Control group) - LLR with central venous pressure reduction (< 5mmHg) Group 2: Group B (Experimental group) - LLR without central venous pressure reduction

Sponsors

Universitätsmedizin Mannheim - Chirurgische Klinik
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Elective LLR • Age equal or greater than 18 years • Written informed consent

Exclusion criteria

Exclusion criteria: • Extrahepatic resection required based on preoperative imaging • Expected lack of compliance • Child B or C liver cirrhosis • Atrial fibrillation (impossibility to validly measure CVP via central venous line) • Impaired mental state or language problems

Design outcomes

Primary

MeasureTime frame
Intraoperative blood loss [mL]—

Secondary

MeasureTime frame
• Blood loss during liver transection • Number of patients requiring transfusions • Operation time • Conversion rate to open hepatic resections • Transecetion time • Need for additional inflow control • Intraoperative complications • Postoperative length of stay • Biochemical blood value tests • Resection margines • Perioperative morbidity and mortality—

Countries

Germany

Contacts

Public ContactNuh N. Rahbari

Universität Heidelberg, Medizinische Fakultät Mannheim, Chirurgische Klinik

nuh.rahbari@umm.de+49621-383-4864

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026