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Incidence and long-term course of subclinical and clinical myocardial damage as well as pulmonary vascular and structural changes in patients with COVID-19

Incidence and long-term course of subclinical and clinical myocardial damage as well as pulmonary vascular and structural changes in patients with COVID-19

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00021727
Enrollment
100
Registered
2020-05-12
Start date
2020-05-12
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

U07.1

Interventions

Group 1: Patients with PCR-secured Sars-Cov2 infection and inpatient treatment are included. During the initial inpatient stay, data of examinations indicated in clinical routine is collected, which c

Sponsors

Universitätsherzzentrum Freiburg Bad Krozingen
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: - PCR-secured SARS-CoV-2 infection - Clinically manifest signs of SARS-CoV-2 infection - Ability / willingness to come to the 6-month follow-up

Exclusion criteria

Exclusion criteria: - Missing written informed consent - Contraindication for MRI examination according to the current guidelines (e.g. metal implants, severe allergy to MRI contrast media) - severe renal failure (creatinine clearance <30ml / min / 1.73m2) - People who are in a dependency or employment relationship with the clinic or examiner stand - Placement in an institution based on a judicial or official order - Demential development or other illness (e.g. substance abuse) that a Understanding of the clarification in the study and / or a legally effective clarification makes unlikely. - pregnancy

Design outcomes

Primary

MeasureTime frame
Left and right ventricular ejection fraction (echo and MRI) at the time of inpatient treatment for Sars-CoV2 infection and after 6 months

Secondary

MeasureTime frame
• Markers for myocardial damage that are not detected by a decrease in the ejection fraction (including blood: highly sensitive troponin T, NT-proBNP / ECG: QRS fragmentation / echo: myocardial strain, pulmonary arterial pressure / MRI: late enhancement ) at the time of inpatient treatment for Sars-CoV2 infection and after 6 months • Cardiovascular event rate within 12 months (death, myocardial infarction, hospitalization for heart failure)

Countries

Germany

Contacts

Public ContactNikolaus Löffelhardt

Universitätsherzzentrum Freiburg Bad Krozingen

nikolaus.loeffelhardt@universitaets-herzzentrum.de07633 4020

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026