N17
Conditions
Interventions
Group 1: In patients with cardiac surgery, urine and blood is collected and biomarkers are determined.
Sponsors
Universitätsklinikum Münster; Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Cardiac Surgery with the use of cardiopulmonary bypass 2. Age > 18 years 3. Informed consent
Exclusion criteria
Exclusion criteria: 1. Historiy of acute kidney injury 2. chronic kidney disease with a glomerular filtration rate < 20 ml/min 3. Dialysis-dependent chronic kidney insufficiency 4. Kidney transplant within the last 12 months 5. Liver failure 6. Primary or secondary hyperaldosteronism 7. Pregnancy or nursing period 8. Persons with any kind of dependency on the investigator or employed by the sponsor or investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of acute kidney injury within 72 h after cardiac surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| • Severity of acute kidney injury within 72 h after cardiac surgery • Severity of acute kidney injury within 72 h after cardiac surgery in patients with /without ACE inhibitors / angiotensin receptor blocker • Renal replacement therapy • Renal recovery • Dialysis dependency at day 90 • Mortality at day 90 • MAKE 90 (=Major adverse kidney events: combined endpoint consisting of renal recovry, dialysis dependency and mortality) • Duration of vasopressor therapy • Duration of vasopressor therapy in patients with / without ACE inhibitors / angtiotensin receptor blocker • Incidence of vasoplegia • Incidence of atrial fibrillation • ICU stay and hospital stay | — |
Countries
Germany
Contacts
Public ContactAlexander Zarbock
Universitätsklinikum Münster Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie
Outcome results
None listed