Antimicrobial skin proteins and peptides and skin microbiome in premature and term infants

Antimicrobial skin proteins and peptides and skin microbiome in premature and term infants - AMP study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00021635

Enrollment

Registered

2020-05-12

Start date

2019-11-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

skin antimicrobial peptides skin microbiome

Interventions

Group 1: Skin rinse samples from premature babies <34 6/7 weeks of gestation on days 0, 7, 14 and 28 after birth are taken and examined for the presence and concentration of antimicrobial peptides by

Eligibility

Sex/Gender

All

Age

No minimum to 2 Days

Inclusion criteria

Inclusion criteria: All infants born at the University of Lübeck will be evaluated for inclusion immediaty after birth. Premature and term infants with with informed consent of parents or legal guardians will be included into the study.

Exclusion criteria

Exclusion criteria: All infants with diseases of the skin, non-european type of skin, missing informed consent of parents or legal guardians or who are clinically not stable enough for skin washing will be excluded.

Design outcomes

Primary

Measure	Time frame
Concentrations of antimicrobial peptides from premature infants <34 6/7 weeks of gestation are compared with those from mature infants. For this purpose, skin rinse samples are taken on days 0, 7, 14 and 28 after birth and examined for the presence and concentration of antimicrobial peptides by ELISA. Material for examining the skin microbiome is obtained from the rinsing samples and examined for the effect of clinical parameters (birth mode, antibiotic therapy).	—

Measure

Time frame

Concentrations of antimicrobial peptides from premature infants <34 6/7 weeks of gestation are compared with those from mature infants. For this purpose, skin rinse samples are taken on days 0, 7, 14 and 28 after birth and examined for the presence and concentration of antimicrobial peptides by ELISA. Material for examining the skin microbiome is obtained from the rinsing samples and examined for the effect of clinical parameters (birth mode, antibiotic therapy).

—

Secondary

Measure	Time frame
Differences in the concentration of different antimicrobial peptides on the skin of mature newborns depending on the mode of birth (spontaneous vs. sectio) Expression of the skin microbiome in premature and mature newborns depending on the antenatal antibiotic exposure Differences in the concentration of various antimicrobial peptides in the skin of premature babies depending on skin care and duration of UV radiation by phototherapy	—

Measure

Time frame

Differences in the concentration of different antimicrobial peptides on the skin of mature newborns depending on the mode of birth (spontaneous vs. sectio) Expression of the skin microbiome in premature and mature newborns depending on the antenatal antibiotic exposure Differences in the concentration of various antimicrobial peptides in the skin of premature babies depending on skin care and duration of UV radiation by phototherapy

—

Countries

Germany

Contacts

Public ContactAlexander Humberg

Universitätsklinikum Schleswig-Holstein, Campus LübeckKlinik für Kinder- und Jugendmedizin

alexander.humberg@uksh.de0451-50077321

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026