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Orthostatic hypotension in patients with Parkinson’s disease and multiple system atrophy: the effect of lower limb compression stockings vs. abdominal binding therapy on physical activity – a single-blinded, randomized, controlled, cross-over study.

Orthostatic hypotension in patients with Parkinson’s disease and multiple system atrophy: the effect of lower limb compression stockings vs. abdominal binding therapy on physical activity – a single-blinded, randomized, controlled, cross-over study.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00021597
Enrollment
17
Registered
2020-05-06
Start date
2018-01-01
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G20.2 G23.2

Interventions

Group 1: Compression stockings Group 2: Abdominal binder therapy

Sponsors

Universitätsklinikum Schleswig-Holstein Campus Kiel
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Patients will be included if they meet the following inclusion criteria: 1. Diagnosis of PD according to the UK Brain Bank Criteria or MSA, Parkinson type, 2. symptomatic OH (OHQ symptom assessment item 1 = 1), and 3. moderate OH (systolic/diastolic blood pressure drop of at least 20/10 mmHg within 3 min of standing or head-up tilt to at least 60° on a tilt table) or severe OH (BP drop = 30/15 mmHg).

Exclusion criteria

Exclusion criteria: Exclusion criteria comprise end stage PD (H & Y stage = 5), OH due to medication side effects (diuretics, alpha adrenergics for bladder disorder, sympatholytics, vasadilatators, antidepressants, antihypertensives), pharmacological treatment of OH (fludrocortisone, midodrine, droxidopa), other severe neurological, psychiatric or cardiac diseases, severe diabetes mellitus, severe peripheral neuropathy, pregnancy/breast feeding, and changes of the medical therapy in the 4 weeks prior to enrollment.

Design outcomes

Primary

MeasureTime frame
Effect of compression stockings versus abdominal binder therapy on physical activity, i.e. number of sit to stand movements per week as a surrogate marker for physical activity—

Secondary

MeasureTime frame
Secondary endpoints comprise the effects on the following domains: quality of life (PDQ-39), blood pressure drop as measured by tilting table, orthostatic symptoms (orthostatic hypotension questionnaire), activities/instrumental activities of daily living (ADL/iADL), PD symptoms (Movement Disorder Society unified Parkinson’s disease rating scale, MDS-UPDRS, parts I-IV), non-motor Parkinson’s disease symptoms (NMSS), autonomic symptoms (Scopa-AUT), clinician/patient global impression (CGI-S, PGI-S), and number of syncopes/severe dizziness/falls (patient diary).—

Countries

Germany

Contacts

Public ContactSteffen Paschen

Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Neurologie

s.paschen@neurologie.uni-kiel.de043150023819

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026