I50.14 I34.0
Conditions
Interventions
Group 1: Patients who had no or only mild MI (mitral regurgitation) at the time of LVAD implantation.
Only those patients in our clinic who are currently supported by the LVAD system and who meet the
Sponsors
Klinik für Herzchirurgie, Rhön-Klinikum, Campus Bad Neustadt
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with an implanted LVAD system (left ventricular support system) and consent form for performing dynamic stress echocardiography and spiroergometry.
Exclusion criteria
Exclusion criteria: • Significant reduction in performance / deterioration of the general condition compared to the last follow-up examination (climbing stairs from a floor at a moderate pace is no longer possible without a break) • manifest cardiac decompensation (peripheral edema with weight gain of> 2 kg in the last 1 to 3 days, shortness of breath, persistent tachycardia / tachyarrhythmia with resting frequency> 100 beats / min, deterioration of the kidney / liver parameters with derailment derailment with equally dosed oral anticoagulation) • ICD triggering (anti-tachycardia pacing or shock delivery) • LVAD flow <3l / min, frequent suction events, technical alarms Significant Hb drop, Hb value <10 g / dl (mostly seen after gastrointestinal bleeding, rarely after spontaneous retroperitoneal bleeding with coagulation derailment) • serious thromboembolic / bleeding complications in the past 3 months (ischemic or hemorrhagic apoplex with persistent neurological deficits)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mitral valve insufficiency at the time of the follow-up examination determined by 2 examination methods: dynamic stress echocardiography for quantification of a hypothesized MI that emerged or increased under load (latent post-LVAD MI), and spiroergometry for determination of the maximum oxygen intake per kg / kg / minute (SvO2) for estimation resilience (cardio-pulmonary reserve). | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival under LVAD support, frequency of inpatient admission, TAPSE (tricuspid annular plane systolic excursion) as an echo parameter for assessing right ventricular pump function, creatinine and glomerular filtration rate (GFR) as a parameter for the progression of chronic renal failure (cNI). | — |
Countries
Germany
Contacts
Public ContactAtanas Jankulovski
Klinik für Herzchirurgie, Rhön-Klinikum, Campus Bad Neustadt
Outcome results
None listed