E85.1 G63 M17
Conditions
Interventions
Group 1: Patients with ATTRv amyloidosis will complete different questionnaires especially capturing pain and autonomic symptoms (PainDetect Questionnaire, PainPredict Questionnaire, Neuropathic Sympt
Sponsors
Universitätsklinikum Schleswig-Holstein Campus Kiel
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Study participants have to suffer from one of the following disease entities: - ATTRv amlyoidosis with polyneuropathy (documented mutation) - polyneuropathy of other etiology - pain caused by knee osteoarthritis Study participants must have signed a consent form in which they declare that they understand the purpose of the study and the procedures used in it and that they consent to the study. Participants must be able to communicate adequately and be able to identify and differentiate the location and intensity of pain and complete the questionnaires used in this study.
Exclusion criteria
Exclusion criteria: Exclusion criteria are pain syndromes of other causes, which could possibly compete with the pain, and severe psychiatric disorders, e.g. severe depression.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of this study is to develop a simple screening tool (history questions and potentially a short sensory testing procedure) to detect ATTRv amyloidosis with polyneuropathy early in the disease course and to distinguish it from other painful neuropathies or diseases with pain in the extremities. For this purpose, cut-off scores with the best discriminative value for ATTRv amyloidosis will be identified by examining the patients with different questionnaires and testing procedures. | — |
Secondary
| Measure | Time frame |
|---|---|
| See Primary Outcome | — |
Countries
Germany
Contacts
Public ContactJuliane Sachau
Sektion Neurologische Schmerzforschung und -therapie, Klinik für Neurologie, Universitätsklinikum Schleswig-Holstein Campus Kiel
Outcome results
None listed