Chronic thromboembolic pulmonary hypertension, Pulmonary endarterectomy, Postoperative cognitive deficits
Conditions
Interventions
Group 1: Intervention group (DBT): additional use of the dynamic bubble trap
Group 2: Control group: no additional filter system
Sponsors
Heart and Brain Research Group, Kooperation des Universitätsklinikums Giessen und der Kerckhoff Klinik Bad Nauheim.Gesundheitszentrum Wetterau, Neurologie.
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Elelective Pulmonary Endarterectomy - Patients aged 18 and older - Informed Consent - German as mother tongue
Exclusion criteria
Exclusion criteria: Any pre-existing neurological or psychiatric disease (in particular cerebral infarction, craniocerebral trauma, manifest depression or dementia) that may influence neuropsychological testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| As a primary endpoint, we will investigate whether or not the neuropsychological outcome was influenced by the use of the dynamic bubble trap (DBT). For this purpose, the neuropsychological outcome will be measured preoperatively and 3 months after surgery with a detailed, objective, neuropsychological test battery. | — |
Secondary
| Measure | Time frame |
|---|---|
| As secondary endpoints, subjective self- and foreign assessment of cognitive deficits, anxiety and depression as well as health-related quality of life will be assessed preoperatively and 3 months after surgery using standardized questionnaires. Postoperative cerebral micro-infarcts will be measured 6-10 days after surgery by diffusion-weighted MRI. The number of microemboli before and after the DBT will be measured with a gas bubble counter. | — |
Countries
Germany
Contacts
Public ContactJasmin El Shazly
Heart and Brain Research Group, Kooperation des Universitätsklinikums Giessen und der Kerckhoff Klinik Bad Nauheim
Outcome results
None listed