U07.1
Conditions
Interventions
Group 1: Questionnaire on potential risk factors for infection (at baseline)
Analysis of the antibody response against SARS-CoV-2 (e.g., by ELISA, Neutralization assays) at baseline then every 6-12 w
Sponsors
Institut für Virologie Uniklinik Köln
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: General inclusion criteria - Age =18 years - In generally good physical condition (Karnofsky-Index =80%) Additional inclusion criterion when a cumulative blood volume of >100 ml is planned to be drawn: - Current or previous laboratory-confirmed SARS-CoV-2 infection
Exclusion criteria
Exclusion criteria: Exclusion criteria when a cumulative blood volume of >100 ml is planned to be drawn: - Hemoglobin <10 g/dl - Symptomatic cardiac disease (e.g., congestive heart failure NYHA =II, coronary artery disease) - History of myocardial infarction - COPD GOLD grade III-IV - Body weight <45 kg (for a blood draw of =250 mL, a minimum body weight of 50 kg is required) - <8 weeks (men) or <12 weeks (women) since last draw of a blood volume of =500 ml
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Prevalence (ELISA) (Baseline) - Risk factors (Questionnaire) (Baseline) - Antibody response (ELISA, neutralization assays) (Baseline, every 6-12 weeks) - Cellular response (cytokine assays) | — |
Countries
Germany
Contacts
Public ContactHenning Grüll
Institut für VirologieUniklinik Köln
Outcome results
None listed