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Selective Intraarterial Radiotherapy (SIRT) with QuiremSpheres: Evaluation of renal and intestinal radioactivity excretion after the Holmium Scout Dose for therapy planning and after SIRT procedures – Aspects of radiation protection and safety

Selective Intraarterial Radiotherapy (SIRT) with QuiremSpheres: Evaluation of renal and intestinal radioactivity excretion after the Holmium Scout Dose for therapy planning and after SIRT procedures – Aspects of radiation protection and safety

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00021427
Enrollment
30
Registered
2020-04-17
Start date
2019-12-19
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C22.0 C78.7

Interventions

Group 1: Amounts of radioactivity are measured in the urine and faeces of patients who underwent a radioembolisation planning procedure with Ho-166 microspheres for 24 h after the procedure. Amounts o

Sponsors

Universitätsklinikum Jena
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with primary (HCC, CCC) and secondary (metastases) malignant liver tumors may undergo SIRT, depending on previous treatments, other clinical, laboratory and imaging data.

Exclusion criteria

Exclusion criteria: Patients with SIRT contraindications (e.g. high tumor load, impaired liver function)

Design outcomes

Primary

MeasureTime frame
To measure the renal and intestinal excretion of Holmium-166 during the first 48h after application of the Scout Dose and after application of the treatment dose.

Secondary

MeasureTime frame
To gain experience using the Holmium Scout Dose, to evaluate the side effect profile of this and of the SIRT with QuiremSpheres. A potential sub-project would be to measure to radiation exposure to the nuclear medicine physician and the radiologist during the procedures.

Countries

Germany

Contacts

Public ContactRobert Drescher

Klinik für Nuklearmedizin, Uniklinikum Jena

robert.drescher@med.uni-jena.de036419329801

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026