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Explorative Study of the Association of Oropharyngeal Microbiota Profiles with SARS-CoV-2 Infection and COVID-19 disease

Explorative Study of the Association of Oropharyngeal Microbiota Profiles with SARS-CoV-2 Infection and COVID-19 disease - OpMiCoV

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00021424
Enrollment
360
Registered
2020-06-12
Start date
2020-04-02
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

U07.1 U07.2

Interventions

Group 1: Within the framework of the tests for infection with SARS-CoV-2 ordered by health authorities or doctors, a broad-based testing of persons at risk (medical staff, contact persons, etc.) by me
e.g. medical staff), b) volunteers who have flu-like symptoms with negative SARS-CoV-2 testing and c) volunteers with positive SARS-CoV-2 testing, who are either asymptomatic, mild or severely ill. Th
mild disease: symptoms of a cold (cough, cold, fever), but at medical discretion no indication for inpatient treatment
survey at the time of the smear test
severe disease: symptoms of infection that require inpatient treatment at the time of the smear test. These patients are followed up until discharge from hospital and the clinical course is recorded (
e.g. medical staff)

Sponsors

German Cancer Research Center (DKFZ)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Subjects who receive a test for SARS- CoV-2 infection for medical or regulatory reasons. - Persons who have understood the informed consent and signed the written consent form.

Exclusion criteria

Exclusion criteria: - Rejection by the patient. - Age < 18 years. - Lack of ability to consent.

Design outcomes

Primary

MeasureTime frame
The main outcome is the association of oropharyngeal microbial diversity and composition with the detection of SARS-CoV-2 in volunteers who have a medical indication for testing for this viral infection.

Secondary

MeasureTime frame
Microbial diversity and composition in asymptomatic, mild and severe Covid-19 patients Collection of clinical data on mild vs. severe Covid-19 patients

Countries

Germany

Contacts

Public ContactChristoph Stein-Thoeringer

German Cancer Research Center (DKFZ)

c.stein-thoeringer@dkfz-heidelberg.de+496221424952

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026