healthy volunteers
Conditions
Interventions
Group 1: This trail is two armed and based on seven appointments. On two days the participants will receive 200 g beef with a standardised rice meal (125 g rice, 30 g margarine, 1.5 salt) as intervent
Sponsors
ZIEL - Insitute for Food and Health
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: - healthy women and men with an age between 18 and 40 - bmi in the range of 17-30 kg/m2 - non smokers - written informed consent
Exclusion criteria
Exclusion criteria: - Smoker - Diseases that affects nutrient resorption, digestion, metabolism and excretion - Chronical illness (e.g. hepatitis B/C, diabetes mellitus) - Acute infectious disease - Antibiotic intake during the last 6 months - Regular medication (excluded: oral contraceptives) - Pregnant women and nursing mothers - Allergies and intolerances against one of the tested foods - Diverticulosis, obstipation during anamnesis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this exploratory study is to investigate the impact of dietary fibres on the production of beef intake biomarkers (in particular TMAO) with targeted metabolomic methods. The primary target value is therefore the plasma TMAO level. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome is to investigate alterations in the microbiom composition in stool samples which may occur due to high amount of dietary fibre in the diet. Furthermore, secondary values are food intake biomarkers, which are also associated with the intake of red meat (e.g. trimethyllysin, carnosin, anserin). | — |
Countries
Germany
Contacts
Public ContactMelanie Haas
ZIEL Institute for Food and Health an der Technischen Universität München
Outcome results
None listed