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Investigation of the relationship between the operative therapy of a high grade stenosis of the internal carotid artery and the cognition function

Investigation of the relationship between the operative therapy of a high grade stenosis of the internal carotid artery and the cognition function

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00021223
Enrollment
30
Registered
2021-06-10
Start date
2021-10-01
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I65.2

Interventions

Group 1: Patients (30 patients) with high-grade asymptomatic stenosis with 60-70% stenosis according to NASCET criteria and flow velocities of over 250-300 cm / s which is an indication for performing

Sponsors

Universitätsklinikum Köln
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with high-grade asymptomatic> 60-70% stenosis of the ACI according to NASCET criteria and flow-velocity of over 250-300 cm / s, as well as symptomatic patients with over 50-99% stenosis of the ACI and flow-velocity of over 200 cm / s are examined. Our inclusion criteria thus correspond to the group for which there is an indication for performing a CEA according to the guidelines of the "European Society for Vascular Surgery".

Exclusion criteria

Exclusion criteria: - Serious systemic inherited or acquired diseases, especially psychiatric or neurological diseases. - Contraindications to performing an MRI scan. - Previous operations or carotid interventions or interventions that significantly affect carotid anatomy, such as radiation in the neck area. - Patients who show severe morphological changes in the MR examination.

Design outcomes

Primary

MeasureTime frame
In thid study we want to investigate how the connectivity of he areas associated with cognitive performance after performing a CEA changed with special attention to the DMN. We also want to measure changes in the volumes of the hippocampus and frontal, parietal and temporal cortex areas and correlate both connectivity and volumetry with neuropsychological tests.

Countries

Germany

Contacts

Public ContactWael Ahmad

Klinik und Poliklinik für Gefäßchirurgie

wael.ahmad@uk-koeln.de022147832403

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026