Analysis of the transsectoral nutritional care of malnourished patients with liver cirrhosis over 6 months (as part of the Joint project “Enteral nutrition in Malnutrition due to diseases of the gastrointestinal tract: from basic understanding to an innovative treatment concept” (EnErGie))

Analysis of the transsectoral nutritional care of malnourished patients with liver cirrhosis over 6 months (as part of the Joint project “Enteral nutrition in Malnutrition due to diseases of the gastrointestinal tract: from basic understanding to an innovative treatment concept” (EnErGie)) - EnErGie longitudinal study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00021181

Enrollment

Registered

2020-04-03

Start date

2019-06-20

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K70.3 K74.6 E44.0 E46

Interventions

Group 1: Malnourished patients with liver cirrhosis receive tube feeding for 10-14 days accompanied and followed by oral nutritional supplements. Intensive nutritional care takes place over a period o

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Diagnosis of malnutrition according to ESPEN / GLIM criteria - Liver cirrhosis (Child-Pugh stadium A-C) based on clinical characteristics, histological findings and / or imaging criteria (sonography, CT or MRI)

Exclusion criteria

Exclusion criteria: - parenteral nutrition in the previous 6 months - ongoing nutritional Intervention (over more than the past 7 days, e.g. intake of oral nutritional supplements) - pregnancy or breastfeeding - pacemaker or implanted defibrillator - tumor diseases in the past 3 years - known hepatocellular carcinoma - state after liver transplantation - TIPS - coexistant chronic pancreatitis

Design outcomes

Primary

Measure	Time frame
The primary outcome is feasibility (in the overall collective): - Dropout rate after the end of nutritional supplementation, after 3 and 6 months after discharge from the clinic - Compliance of oral nutritional supplements drinking: ingested versus recommended drinking quantity - Compliance in the nutritional counsellig: number of performed, postponed and canceled vis-à-vis therapy sessions and phone calls The primary aims of the study are: 1. Testing the feasibility and tolerance (therapy adherence) of a cross-sector, nutritional care (standard of care) in malnourished patients with liver cirrhosis, which is regarded as particularly challenging by the outpatient follow-up care over a period of 6 months. 2. The collection of biochemical parameters, which are analyzed together with data from the EnErGie cross-sectional study (DRKS00021124) in a complex mechanistic model on the genesis and course of malnutrition and sarcopenia.	—

Measure

Time frame

The primary outcome is feasibility (in the overall collective): - Dropout rate after the end of nutritional supplementation, after 3 and 6 months after discharge from the clinic - Compliance of oral nutritional supplements drinking: ingested versus recommended drinking quantity - Compliance in the nutritional counsellig: number of performed, postponed and canceled vis-à-vis therapy sessions and phone calls The primary aims of the study are: 1. Testing the feasibility and tolerance (therapy adherence) of a cross-sector, nutritional care (standard of care) in malnourished patients with liver cirrhosis, which is regarded as particularly challenging by the outpatient follow-up care over a period of 6 months. 2. The collection of biochemical parameters, which are analyzed together with data from the EnErGie cross-sectional study (DRKS00021124) in a complex mechanistic model on the genesis and course of malnutrition and sarcopenia.

—

Secondary

Measure	Time frame
Secondary goals are the reduction of malnutrition and of sarcopenia, the improvement of anthropometric measurements, body composition (increase of the skeletal muscle mass), nutritional quality, systemic inflammation and other clinical-chemical blood parameters ??as well as muscle strength and function.	—

Countries

Germany

Contacts

Public ContactGeorg Lamprecht

Klinik für Innere Medizin, Abteilung für Gastroenterologie und Endokrinologie

georg.lamprecht@med.uni-rostock.de+493814947481

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026