Trauma-focused psychodynamic therapy and STAIR Narrative Therapy of post-traumatic stress disorder related to childhood maltreatment: a multicenter randomized clinical trial examining psychological, biological and health economic outcomes

Trauma-focused psychodynamic therapy and STAIR Narrative Therapy of post-traumatic stress disorder related to childhood maltreatment: a multicenter randomized clinical trial examining psychological, biological and health economic outcomes - ENHANCE

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

DRKS

Registry ID

DRKS00021142

Enrollment

328

Registered

2020-03-24

Start date

2020-10-31

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F43.1

Interventions

Group 1: STAIR Narrative Therapy Group 2: Trauma-Focused Psychodynamic Therapy (TF-PDT) Group 3: Minimal Attention Waiting List (MA-WL)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Persons of all sexes with PTSD related to CM by a caretaker or person in authority over them before the age of 18 years, age: 18 to 65 years; continuing stable medication been ongoing for at least 3 months prior to study entry is permitted.

Exclusion criteria

Exclusion criteria: psychotic disorders, risk of suicide, ongoing abuse, acute substance related disorder, borderline personality disorder, dissociative identity disorder, organic mental disorder, severe medical conditions, concurrent psychotherapy.

Design outcomes

Primary

Measure	Time frame
CAPS-5 total score (post, 6 and 12 months after treatment termination)	—

Secondary

Measure	Time frame
remission (CAPS-Total <20), response (50%-reduction of CAPS-total-score), complex PTSD (International Trauma Questionnaire), dissociative symptoms (Dissociative Experience Scale) depression (Beck Depression Inventory II), Clinical Global Impression rating for improvement (CGI-I), mentalization (Mentalization Questionnaire), attachment (Experiences in Close Relationships-Revised), personality organization (Borderline Personality Inventory), and number of treatment drop-outs Assessements post, 6 and 12 months after treatment termination	—

Measure

Time frame

remission (CAPS-Total <20), response (50%-reduction of CAPS-total-score), complex PTSD (International Trauma Questionnaire), dissociative symptoms (Dissociative Experience Scale) depression (Beck Depression Inventory II), Clinical Global Impression rating for improvement (CGI-I), mentalization (Mentalization Questionnaire), attachment (Experiences in Close Relationships-Revised), personality organization (Borderline Personality Inventory), and number of treatment drop-outs Assessements post, 6 and 12 months after treatment termination

—

Countries

Germany

Contacts

Public ContactFatima Nöske

Klinik für Psychsomatik und Psychotherapie der Universität Giessen

enhance@psycho.med.uni-giessen.de0641 9945663

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 20, 2026