T84.5
Conditions
Interventions
Group 1: Treatment of multidrug-resistant pathogens resistant to all types of oral antibiotics by Outpatient Parenteral Antimicrobial Therapy (OPAT). As part of a multi-stage revision arthroplasty in
Sponsors
BG University Hospital Bergmannsheil
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: The inclusion criterion was the detection of a pathogen that could not be optimally treated with oral antibiotics according to the PRO-IMPLANT Foundation based on the management concept of Zimmerli et al. and adapted by Trampuz et al.
Exclusion criteria
Exclusion criteria: Patients with a mental disability or paraplegic symptoms are excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the successful infection eradication of multidrug-resistant (MDR) pathogens in periprosthetic joint infections with self-administered outpatient parenteral antimicrobial therapy (S-OPAT) in multi-stage revision arthroplasty. It is characterized by reimplantation of a prosthesis and completion of the antimicrobial therapy with an average duration time of 12 weeks. Patients are included in an ongoing follow-up to obtain data from long-term results, following the international consensus of successful PJI treatment by Diaz-Ledezma et al. | — |
Secondary
| Measure | Time frame |
|---|---|
| I) Evaluation of long-term outcome (10 years after the end of treatment) II) Assessment of complications related to APAT: 1) Adverse drug reactions (ADRs) 2) Catheter-related complications (CRC) Patients visited the hospital or their general practitioners at least once a week for follow-up clinical examination. | — |
Countries
Germany
Contacts
Public ContactHinnerk Baecker
BG University Hospital Bergmannsheil
Outcome results
None listed