J45
Conditions
Interventions
Group 1: Adult patients suspected to suffer from asthma and who visit one of the participating practices of pneumologists will perform a FeNO measurement with the device NIOX VERO®. Afterwards, they w
Sponsors
Klinikum rechts der Isar, Institut für Allgemeinmedizin und Versorgungsforschung der Technischen Universität München
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: All adult patients suspected to suffer from asthma, visiting one of the participating practices of pneumologists and who declare their written informed consent to participate in the study will be consecutively included.
Exclusion criteria
Exclusion criteria: Patients with the following criteria are not included: • Patients who do not agree to participate in this study • Patients younger than 18 years • Patients who do not understand the meaning of the study due to a lack of knowledge of the German language • Patients with an already diagnosed obstructive airway disease • Patients who smoked on the day of the examination (falsification of the FeNO measurement and bronchial provocation test) • Patients who have eaten a large amount of nitrate-rich diet (e.g. salad) before the examination (false high FeNO values) • Patients with airway infection = 6 weeks prior study enrolement (distortion of the FeNO measurement and/or bronchial provocation test)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity and specificity of FeNO measurement at a cut-off value of 50ppb for an asthma diagnosis | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive predictive value (PPV) and negative predictive value (NPV) of FeNO measurement at a cut-off value of 50ppb regarding the diagnosis of asthma. Determination of PPV for an asthma diagnosis at a FeNO cut-off value of 33ppb, if the symptoms "Allergic rhinitis" and "Wheezing" are present. Additionally, the PPV at a FeNO cut-off value of 33ppb is determined regarding ICS responsiveness. | — |
Countries
Germany
Contacts
Public ContactChristina Kellerer
Klinikum rechts der Isar, Institut für Allgemeinmedizin und Versorgungsforschung der Technischen Universität München
Outcome results
None listed