C25.9
Conditions
Interventions
Group 1: EUS fine-needle biopsy (needle size G19 and G22) from mass lesions of the pancreas, creation of PDA organoids
Sponsors
Klinikum der Universität München, Campus Großhadern
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Pancreatic mass on imaging suspicious of pancreatic cancer, clinical indication for histology sampling, absence of contraindications for EUS FNA, age >18 years, patient's informed consent
Exclusion criteria
Exclusion criteria: Pregnancy, uncorrectable coagulopathy, MD-IPMN, age <18 years, repeated biopsy with unclear results of first biopsy, no patient's informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success in tissue extraction is defined by the amount of cells for cytological/histological examination and its explanatory power for evaluation and furthermore the quality/stability of the tissue plugs, which is reflected by the possibility to examine – potentially malign – cell structures. | — |
Secondary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy, Procedure associated complication, Percentage of individualized treatment decisions taken, Advancement of organoid generation by co-culture mimicking microenvironment, Sample evaluation (suction, no suction, amout of tissue harvested) | — |
Countries
Germany
Contacts
Public ContactGeorg Beyer
LMU Klinikum Medizinischen Klinik und Poliklinik II
Outcome results
None listed