Healthy patients Prevention of caries, gingivitis, periodontitis
Conditions
Interventions
Group 1: The subjects are recruited from 35-45 dental students at the ZZMK Greifswald, who are healthy from a dental and general medical point of view. Physiological baseline values as well as experim
Sponsors
Zentrum für Zahn-, Mund- und Kieferheilkunde der Universitätsmedizin Greifswald
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: • female and male subjects who are at least 18 years old, • signed declaration of consent • Willingness and ability to meet the study requirements
Exclusion criteria
Exclusion criteria: • Systemic diseases, antibiotic or drug use in the past 6 months that would affect PMN and / or salivary function and saliva and sulcus fluid composition • Periodontitis treatment in the past 6 months • Pregnancy and breast feeding period • Simultaneous participation in another clinical trial • lack of compliance • Alcoholic, smoker, drug or drug addict Known hypersensitivity or allergies to the ingredients used in the investigational medicinal products, e.g. Milk allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dependence of hypothiocyanite production on H2O2 content in vitro and in vivo | — |
Secondary
| Measure | Time frame |
|---|---|
| Circadian and nutritional determination of OSCN, SCN, H2O2, nitrate / nitrite content in saliva | — |
Countries
Germany
Contacts
Public ContactAlexander Welk
Poliklinik für Zahnerhaltung, Parodontologie, Endodontologie, Präventive Zahnmedizin und Kinderzahnheilkunde im Zentrum für Zahn-, Mund- und Kieferheilkunde der Universitätsmedizin der Ernst-Moritz-Arndt Universität Greifswald
Outcome results
None listed