PONV R11
Conditions
Interventions
Group 1: Patients undergoing elective surgery will be assessed for known PONV risk factors, such as Apfel score, age and duration of anesthesia, and also an rs2165870 SNP and an rs349358 SNP. A preope
Sponsors
Universitätsklinikum Essen, Klinik für Anästhesiologie und Intensivmedizin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: -Patients for whom the indication for surgery was given by colleagues from the surgical disciplines at Essen University Hospital (gynaecology, otorhinolaryngology, urology, ophthalmology, trauma surgery, neurosurgery, general surgery) -Medium-difficulty surgery with an expected surgery duration >30 minutes and < 5 hours and immediate postoperative extubation of the patient -surgeries where the anaesthetic induction and maintenance is planned according to clinic internal standards
Exclusion criteria
Exclusion criteria: -rejection of the study participation by the patient -regional anaesthesia -outpatient operations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Which factors (genetic factors: CHRM3 rs2165870 and the KCNB2 rs349358, factors of the Apfel score, age and length of anaesthesia) can best predict PONV incidence at different points in time (recovery room, 2-6 hours and 6-24 hours)? | — |
Secondary
| Measure | Time frame |
|---|---|
| Can the association of further SNPs with PONV be confirmed? | — |
Countries
Germany
Contacts
Public ContactStefanie Klenke
Universitätsklinikum Essen
Outcome results
None listed