Directional deep brain stimulation of the posterior subthalamic area for essential tremor increases therapeutic window

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00021015

Enrollment

Registered

2020-03-04

Start date

2017-05-23

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G25.0 R27.0

Interventions

Group 1: Directional Stimulation: Clinical Scores for tremor (TRS, TETRAS) and ataxia (mICARS, SARA) were carried out. In randomised order

5min wash-out period between conditions Group 2: Omnidirectional stimulation: Clinical Scores for tremor (TRS, TETRAS) and ataxia (mICARS, SARA) were carried out. In randomised order

5min wash-out period between conditions Group 3: Stimulation-OFF (baseline) Clinical Scores for tremor (TRS, TETRAS) and ataxia (mICARS, SARA) were carried out. In randomised order

5min wash-out period between conditions

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Clinical diagnosis of essential tremor Patient consent

Exclusion criteria

Exclusion criteria: Further neurological conditions Insufficient response to DBS Othe rconditions, which would hamper the patient understanding of the study protocol

Design outcomes

Primary

Measure	Time frame
therapeutic window as difference between effect threshold and side effect threshold	—

Secondary

Measure	Time frame
Clinical efficiancy for tremor (TRS,TETRAS scales) and ataxia (mICARS, SARA scales) volume of neuronal activation energy consumption	—

Countries

Germany

Contacts

Public ContactPetyo Nikolov

UKD

petyo.nikolov29@abv.bg02118118075

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026