Influence of Positive End-expiratory Pressure (PEEP) on Ventilation, Compliance and Oxygenation in Trendelenburg Positioning during Robotic-assisted Surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00021009

Enrollment

Registered

2020-03-11

Start date

2020-04-09

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C61

Interventions

Group 1: As we start the measurements of this interventional study at standard settings and go back to standard settings after completing the intervention, each patient serves as his own control. Wit

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: written consent age > 18 elective laparoscopic robotic-assisted radical prostatectomy ASA classification I-III BMI < 30 kg x m-2

Exclusion criteria

Exclusion criteria: disapproval of the patient age < 18 years pulmonary disease contraindications for EIT measurements (active implants, e.g. pacemaker, cardioverter) BMI = 30 kg x m-2

Design outcomes

Primary

Measure	Time frame
Primary outcome is the homogeneity in terms of regional ventilation indicated by the ratio of dorsal and ventral ventilation (electroimpedance tomography). We will compare the ventilation in Trendelenburg positioning while applying the standard PEEP (7 mbar) with ventilation while applying the individually found "best PEEP" (indicated by horizontal intra-tidal compliance). Because electrocauterisation is less used during urethral anastomosis and could affect electroimpedance tomography, measurements will take place during this phase of the operation.	—

Measure

Time frame

Primary outcome is the homogeneity in terms of regional ventilation indicated by the ratio of dorsal and ventral ventilation (electroimpedance tomography). We will compare the ventilation in Trendelenburg positioning while applying the standard PEEP (7 mbar) with ventilation while applying the individually found "best PEEP" (indicated by horizontal intra-tidal compliance). Because electrocauterisation is less used during urethral anastomosis and could affect electroimpedance tomography, measurements will take place during this phase of the operation.

—

Secondary

Measure	Time frame
Dynamic compliance, FiO2, FeO2, PaO2, SpO2, cerebral oxygenation	—

Countries

Germany

Contacts

Public ContactSteffen Wirth

Universitätsklinikum Freiburg Klinik für Anästhesiologie und Intensivmedizin

steffen.wirth@uniklinik-freiburg.de0761 270 23 920

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026