B57
Conditions
Interventions
Group 1: Patients with evidence of infection with T. cruzi.
After obtaining informed consent, patients will be asked to donate 20ml of additional blood in the context of a clinically indicated venipun
Sponsors
Charité Campus Charité Mitte
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: • Positive serology for infection with T. cruzi according to WHO standard (except for healthy controls) • Written informed consent according to ICH-GCP standard procedures • Minimum age 18 years • Maximum age 65 years • Patient meets criteria for at least one of the five clinical categories (IND, CAD, GID, CGD, HEC)*
Exclusion criteria
Exclusion criteria: • Known active or chronic infections other than T. cruzi infection • Known HIV-infection • History of, or current autoimmune disease • Medical history of any cardiac or gastrointestinal disease unrelated to Chagas disease • Immunosuppression by medication or other diseases • Intake of micronutrient supplementation • Diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical validation of a new test for autoantibodies in chronic chagas disease | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of autoantibodies with manifestations of chronic chagas disease, selenium status of patients with chronic chagas disease | — |
Countries
Bolivia
Contacts
Public ContactThomas Zoller
Fächerverbund Infektiologie, Pneumologie und Intensivmedizin, Charité - Universitätsmedizin Berlin
Outcome results
None listed