F32.0 F32.1 F32.2 F33.0 F33.1 F33.2 F43.2
Conditions
Interventions
Group 1: Measurement of objective sleep quality, assessment of subjective sleep quality and measurement of cortisol and alpha-amylase release after awakening in children and young people with depressi
Sponsors
Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie der Universität Regensburg am Bezirksklinikum Regensburg
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: General inclusion criteria of the index and control group • Age at the time of examination: 12 -18 years • Informed consent and signed declaration of consent of study participants and their parents/ legal representatives • Sufficient understanding of the German language • No intake of psychotropic drugs or glucocorticoid-containing drugs Inclusion criteria of the index group • Depressive disorder according the diagnostic criterias of ICD-10 (including F32.0-Mild depressive episode, F32.1-Moderate depressive episode, F32.2- Severe depressive episode without psychotic symptoms, F 43.21- Adjustment disorder with longer depressed mood, F33.0 Recurrent depressive disorder, current episode mild, F33.1 Recurrent depressive disorder, current episode moderate, F33.2 Recurrent depressive disorder, current episode severe without psychotic symptoms) Inclusion criteria of the control group • No history of psychiatric or neurological diseases • No current psychiatric illness requiring treatment
Exclusion criteria
Exclusion criteria: General exclusion criteria of the index and control group • Lacking informed consent or signed declaration of consent of study participants or their parents/ legal representatives • Acute psychiatric condition or psychotic disorder, which may affect the ability to consent • Acute suicidality • Pregnancy • Intake of antidepressant drugs or glucocorticoid-containing drugs • Cannabis use within 3 months before participation • Neurological or endocrinological diseases, which may affect brain physiology or relevant endocrinological parameters (especially diseases concerning hypothalamus, hypophysis and the adrenal glands) Exclusion criteria of the index group • comorbid anxiety disorder, emotional disorder as well as social behaviour disorder are no exclusion criteria, furthermore no psychiatric comorbidities (exclusion comorbidities: schizophrenia, post-traumatic stress disorder, attention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, obsessive-compulsive disorder, dissociative disorders, sleep-wakefulness disturbances, eating disorder, substance use disorder) Exclusion criteria of the control group • Meeting criteria of ICD-10 or DSM-5 depressive disorder • Current or past psychiatric or neurological disorder • Current or past psychiatric or psychotherapeutic treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -objective sleep quality measured by activity tracking during 7 consecutive days (Sunday-Sunday) -subjective sleep quality by filling in self-designed questionnaires in the morning after activity tracking during 7 days and comparative by filling in -Sleep Survey A (SF-A/R) after the seventh night -course of cortisol and alpha-amylase after awakening by saliva samples on 3 days at three exactly defined times (Tuesday-Thursday) at three exactly defined time (after awakening, 30 minutes after awakening, 45 minutes after awakening) | — |
Secondary
| Measure | Time frame |
|---|---|
| Examination of severity of depressive symptoms and further psychopathologies by: -BDI-II: Beck Depression Inventory II(BDI 2) -BAI: Beck Anxiety Inventory (BAI) -M.I.N.I- KID: Mini-international Neuropsychiatric Interviews for children and adolescents (M.I.N.I Kid 6.0), supplemented by Paykel's scale -Sleep Survey B (SF-B/R) -Stress and Coping Questionnaire for Children and Adolescents -Pubertal Development Scale (PDS) -Self-designed questionnaire for long-term sleeping habits Additionally for index group: -Self-designed questionnaire assessing changes in sleep quality occuring simultaneously with the depressive disorder | — |
Countries
Germany
Contacts
Public ContactRomuald Brunner
Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie der Universität Regensburg am Bezirksklinikum Regensburg
Outcome results
None listed