M31.1
Conditions
Interventions
Group 1: patients undergoing minor peripheral vascular surgery (Carotid-TEA)
Group 2: patients undergoing peripheral vascular surgery (Femoral-TEA, bypass grafting of the lower extremity)
Group 3: pat
Sponsors
Hämophiliezentrum, Institut für Transfusionsmedizin, Medizinische Klinik III, Goethe Universitätsklinikum
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patient information and written informed consent 2. Age of majority (=>18 years) 3. patients of the Clinic for Vascular and Endovascular surgery undergoing one of the following procedures: Carotid TEA, Femoral TEA/bypass grafting of the lower extremity, EVAR, open aortic surgery
Exclusion criteria
Exclusion criteria: 1. missing patient information or informed consent 2. known TTP in medical history 3. current pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Kinetics of ADAMTS-13 activity in time course by blood sampling (5 time points: pre-, intra-(60 and 120 min post incision), postoperativ (2 d and 4 d post surgery). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood sampling. Determination at 5 time points [pre, intra (60, 120 min), postoperative (2d, 4d post surgery)]: platelet number, vWF-multimeres, vWF-Antigen, vWF-activity und lactate Dehydrogenase (LDH), fibrinogen, INR, PTT, FVIII, FXIII - - angiogenetic parameters like HIF-1-alpha, VEGF, VEGFR1, VEGFR2, angiopoetin, Interleukin-6, Interleukin-8 Determination at 2 time points : preoperativ, 2d post surgery: -platelet function regarding ASS resistances Additional documentation of: ADAMTS13 inhibitor, intraoperative volume substitution (Erythrozyte concentrate und FFP) | — |
Countries
Germany
Contacts
Public ContactWolfgang Miesbach
Hämophiliezentrum, Institut für Transfusionsmedizin, Medizinische Klinik III, Goethe Universitätsklinikum
Outcome results
None listed