The effect of a collagen matrix on periodontal regeneration in intrabony defects - a randomised, controlled, clinical study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00020809

Enrollment

Registered

2020-02-13

Start date

2020-02-16

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K05.3

Interventions

Group 1: Periodontal surgery in intrabony defects: - minimal invasive surgical technique with collagen matrix Group 2: Periodontal surgery in intrabony defects: - minimal invasive surgical technique w

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Minimum Age of 18 years - Periodontitis patients - at least on intrabony defect with a intraosseous part of 3 mm on a single rooted tooth or a smooth surface of a multi-root tooth without furcation involvement -good oral hygiene - under 25% Plaque after non-surgical therapy

Exclusion criteria

Exclusion criteria: - Sign of an acute infection - Previous surgical intervention in the planned operating area - Uncontrolled diabetes mellitus (HbA1c> 7) - Pregnancy or breastfeeding - Patients with a known allergy to collagen - Long-term cortisone therapy - Autoimmune diseases - Radiation in the operating area - Unhealed malignant systemic diseases (e.g. leukemia, carcinomas, etc.)

Design outcomes

Primary

Measure	Time frame
Clinical attachment gain after 6 and 12 months	—

Secondary

Measure	Time frame
After 6 and 12 months: probing depth reduction (mm) bleeding on probing reduction (%) radiologic bone fill (%) After 2-7-14 days: Early healing index (EHI - Wachtel et al.)	—

Countries

Germany

Contacts

Public ContactJean-Claude Imber

Poliklinik für Parodontologie und Zahnerhaltung

kary@uni-mainz.de+49 (0) 6131 3058

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026