Bioavailability of epigallocatechin gallate and epicatechin
Conditions
Interventions
Group 1: Epigallocatechin gallate, 50 mg p.o. capsule, once
Group 2: Epigallocatechin gallate + Piperine, 50 mg + 20 mg p.o. capsule, once
Group 3: Epicatechin, 50 mg p.o. capsule, once
Group 4: Epica
Sponsors
Universität Bonn, Institut für Ernährungs- und Lebensmittelwissenschaften, Lebensmittelwissenschaft
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: - Age: 18-50 years - Normal weight, i.e. according to WHO (2004) BMI 18.5 - 24.9 kg/m2 - Written declaration of consent - Voluntary participation
Exclusion criteria
Exclusion criteria: - Smoking - Pregnancy (to be checked by pregnancy test or medical information; a pregnancy test will be provided) - Lactation - Frequent green tea consumption (more than three cups per week) - Frequent consumption of cocoa (corresponding to 50 g dark chocolate per day) - Known allergy to pepper or mugwort ("Celery-carrot-mugwort spice syndrome") - Known diseases and conditions affecting the bioavailability or metabolism and excretion of flavanols, e.g. malabsorption syndrome, diseases of the thyroid, kidneys and liver, coronary heart disease, diabetes mellitus, chronic inflammatory diseases - Regular intake of drugs that could have an influence on the target parameters - Taking food supplements (especially flavanol-containing ones such as cocoa and green tea extract, as well as caffeine) - Misuse of alcohol, medication and/or drugs (BTMG or other psychotropic substances) - Known infection with hepatitis B, hepatitis C or HIV - Limited legal capacity - Participation in another clinical study (current or in the past month) - Any other condition that, in the opinion of the investigator, makes the subject unsuitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of EGCg and epicatechin as well as metabolites in blood plasma; measurement by HPLC-CEAD scheduled within one month after the last intervention. | — |
Countries
Germany
Contacts
Public ContactBenno Zimmermann
Universität Bonn, Institut für Ernährungs- und Lebensmittelwissenschaften, Lebensmittelwissenschaft
Outcome results
None listed