DSM-5
Conditions
Interventions
Group 1: Subjects with an alcohol use disorder according to DSM-5 and healthy subjects will be enrolled and followed for 1 year. They will attend 4 direct study visits (neuropsychology, questionnaires
Sponsors
Charité - Universitätsmedizin Berlin Klinik für Psychiatrie und Psychotherapie
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: For all participants: • Age between 16-65 • Sufficient level of german language • Ability to understand the study protocol and to give an informed consent • Will to use an android smartphone Additional for the participants with an alcohol use disorder: • Alcohol use disorder with 2 to 9 fullfilled DSM-5 diagnostic criteria but without need for a medically assisted alcohol withdrawal treatment or another acute therapeutic intervention
Exclusion criteria
Exclusion criteria: General: • Consumption of drugs or medicines, which interact with the central nervous system, in the last 10 days or if the use dates back less than 5 half-life periods • Contraindications for MRT scans (claustrophobia, pacemaker, artificial heart valve, cochlea implant, objects from metal in head or body, vascular clamps, large tattoos in the head and neck region, etc.) or brain and head anomalies which preclude MRT scans • DSM-5 bipolar disorder, psychotic disorder, schizophrenia or disorder from the schizophrenic spectrum, or substance addiction except from alcohol, nicotine, or cannabis in medical history • Severe injury of head or other severe disease of central nervous system (e.g., dementia, Parkinson’s disease, multiple sclerosis) in medical history • Presence of a psychiatric disorder (for healthy controls) For women in childbearing age: Pregnancy, breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This research project aims at identifying (i) biological and environmental factors which predict trajectories of addictive disorders and (ii) molecular, neurobehavioral, and neurocognitive mechanisms which underlie the loss and the regain of control over substance use. | — |
Countries
Germany
Contacts
Public ContactHeike Tost
Zentralinstitut für Seelische Gesundheit
Outcome results
None listed