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AChE-activity in critically ill patients with suspected septic encephalopathy: a prospective, single-centre study

AChE-activity in critically ill patients with suspected septic encephalopathy: a prospective, single-centre study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00020542
Enrollment
250
Registered
2020-01-27
Start date
2017-03-01
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

septic associated encephalopathy F05.9

Interventions

Group 1: Allocation to arm 1: All patients who were admitted to the operative intensive care unit of the Ulm University Hospital, Clinic for Anaesthesiology and were delirious at the time of admission

Sponsors

Klinik für Anästhesiologie, Universitätsklinikum Ulm, Leiter Interdisziplinäre Operative Intensivmedizin
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Necessity of intensive care therapy (emergencies or elective operated patients with postoperative ICU monitoring) Age> 18 years Minimum stay in the intensive care unit of at least 24 hours sufficient knowledge of German (understanding and language) Agreement to participate in the study

Exclusion criteria

Exclusion criteria: Age > 18 years less than 2 consecutive readings of esterase activity missing declaration of consent (verbally and or in writing)

Design outcomes

Primary

MeasureTime frame
Is the longitudinal recording of the erythrocytic acetylcholinesterase activity in intensive care patients with sepsis and the clinical suspicion of a septic associated encephalopathy suitable for confirming this as a differential diagnosis within the syndrome complex delirium and does the erythrocytic AChE-activity differ statistically significant in septic patients with suspicion of a septic associated encephalopathy compared to non septic critically ill patients?

Secondary

MeasureTime frame
Delirium incidence, number of patients with sepsis within the enrolled patient population, activity of butyrylcholinesterase activity

Countries

Germany

Contacts

Public ContactEberhard Barth

Universitätsklinikum Ulm Klinik für Anästhesiologie

eberhard.barth@uniklinik-ulm.de0731-500-60233

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 17, 2026