E63.8
Conditions
Interventions
Group 1: [D9-Methyl]-Choline chloride 3.6 mg/kg, blood samples 5 min before and 0,5h, 1h, 1,5h, 2h, 2,5h, 3h, 4h, 5h, 6h, 9h, 24h, 33h, 48h, 3d, 4d und 7d after intake, wash-out phase of 6 weeks.
Grou
Sponsors
Universitätsklinikum Tübingen
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. >= 18 years 2. male
Exclusion criteria
Exclusion criteria: 1. chronic alcohol abuse 2. acute diseases 3. chronic diseases that change the lipid and cholin metabolism (i.e. untreated Hypothyreosis, Hyperthyreosis, diseases of the lipid metabolism, diseases of the digestive tract and his glands, diabetes, pancreatitis, chronic kidney diseases, ventricular funcitonal limitations that influence the liver function) 4. vegan diet 5. nutritional supplements containing choline
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC of the D9-choline plasma concentration | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. AUC of D9-Batain 2. AUC of D9-PC 3. Time until the maximum plasma concentration of D9-choline is reached 4. Time until the maximum plasma concentration of D9-choline derivates is reached 5. Velocity of increase and decrease of plasma concentrations during 7 days 6. Distribution of the labeling to the different D9-choline labeled metabolites | — |
Countries
Germany
Contacts
Public ContactWolfgang Bernhard
Universitätsklinik für Kinder- und Jugendheilkunde
Outcome results
None listed