Non-interventional study on the prevalence of cardiac amyloidosis in patients with higher-grade aortic valve stenosis - evaluation using Tc99-SPECT / CT and cardiac MRI (CMR)

Non-interventional study on the prevalence of cardiac amyloidosis in patients with higher-grade aortic valve stenosis - evaluation using Tc99-SPECT / CT and cardiac MRI (CMR) - NIS-TAVI-AMY

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00020481

Enrollment

400

Registered

2020-01-14

Start date

2020-01-14

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I08

Interventions

Group 1: Prospective data collection of patients with confirmed higher grade aortic stenosis.

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with higher grade aortic stenosis (valve opening area 40mmHg, vmax> 4m / sec), performing a Tc99-SPECT / CT based on justifying clinical indication, age =18 years, written consent of the patient for prospective data collection regarding Tc99-SPECT / CT, possibly regarding CMR and follow-up.

Exclusion criteria

Exclusion criteria: Patients unable to give consent.

Design outcomes

Primary

Measure	Time frame
Determination of the prevalence of cardiac amyloidosis in patients with higher grade aortic valve stenosis - evaluation using non-invasive imaging: SPECT/CT or cardiac MRI (CMR).	—

Secondary

Measure	Time frame
Correlation of cardiac MRI (T1/T2 mapping) to quantitative SPECT / CT evaluation. Follow-up of the patients with regard to the prognostic relevance of the imaging examinations for any undesirable cardiac events in an observation period of 2 years.	—

Countries

Germany

Contacts

Public ContactSimon Greulich

Universitätsklinikum Tübingen, Innere Medizin III, Kardiologie & Kreislauferkrankungen

simon.greulich@med.uni-tuebingen.de07071-2968888

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026