E63.8
Conditions
Interventions
Group 1: Choline chlorid 740mg , blood samples 0,1h before and 1h, 1,5h, 2h, 2,5h, 3h, 4h, 5h, 6h, 9h und 24h Std. after intake, wash-out phase of one week
Group 2: Choline bitartrate 1336mg, blood sa
Sponsors
Universitätsklinikum Tübingen
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. >= 18 years 2. male
Exclusion criteria
Exclusion criteria: 1. chronic alcohol abuse 2. acute diseases 3. chronic diseases that change the lipid and choline metabolism (i.e. untreated Hypothyreosis, Hyperthyreosis, diseases of the lipid metabolism, diseases of the digestive tract and his glands, diabetes, pancreatitis, chronic kidney diseases, ventricular functional limitations that influence the liver function) 4. vegan diet 5. nutritional supplements containing choline
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC of the choline plasma concentration 0h-24h | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change of plasma concentration of choline within 24h 2. Change of plasma concentrations of metabolites within 24h | — |
Countries
Germany
Contacts
Public ContactWolfgang Bernhard
Universitätsklinik für Kinder- und Jugendheilkunde
Outcome results
None listed