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Grafting extraction sockets by means of deproteinized bovine bone mineral with 10% collagen (Geistlich Bio-Oss® Collagen) at the bone level and application of a collagen matrix (Geistlich Mucograft® Seal) at the soft tissue level: Histomorphometric outcome in humans after 4 months of healing

Grafting extraction sockets by means of deproteinized bovine bone mineral with 10% collagen (Geistlich Bio-Oss® Collagen) at the bone level and application of a collagen matrix (Geistlich Mucograft® Seal) at the soft tissue level: Histomorphometric outcome in humans after 4 months of healing

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00020451
Enrollment
12
Registered
2020-01-30
Start date
2016-05-24
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K08.1 K08.2

Interventions

Group 1: Eleven adult patients scheduled for tooth extraction, alveolar ridge preservation with implant placement Type 3 (delayed
between 12 and 16 weeks, ARP 1.1) or Type 4 (standard placement in a healed ridge
after more than 16 weeks, ARP 2.1) with DMBB+C / CM and implant supported restoration in the maxilla or mandible with at least one primarily four-walled extraction socket were included. The patients
Universitätsklinik für Zahn-, Mund- und Kieferheilkunde, Hugstetterstr. 55, Freiburg im Breisgau, Germany).

Sponsors

Danube Private University GmbH (DPU)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Adult patients of sound mind (i.e. consent patients) • At least one primarily four-walled extraction socket • Good general health • Full-mouth plaque score (FMPS) = 20% • Full-mouth bleeding score (FMBS) = 20% • Absence of residual periodontal infection • Scheduled for alveolar ridge preservation with DMBB+C and CM before enrolment • Willing to adhere to a strict Supportive Periodontal Therapy (SPT) protocol

Exclusion criteria

Exclusion criteria: • Minors • Pregnancy / breastfeeding • Patients taking medications that could influence bone metabolism • Patients with uncontrolled or poorly controlled diabetes • Patients using anticoagulants • Patients requiring antibiotic prophylaxis • Smokers with more than five cig./day • Patients with known allergic reactions/sensitivity against collagen products • Patients presenting unstable or life-threatening conditions

Design outcomes

Primary

MeasureTime frame
Percentage newly formed bone. After a healing period of 4 to 6.5 months a biopsy with a trepan bur was taken and histomorphometric analyses done.—

Secondary

MeasureTime frame
Percentage residual bovine bone mineral and percentage new soft tissue, bone marrow. After a healing period of 4 to 6.5 months a biopsy with a trepan bur was taken and histomorphometric analyses done.—

Countries

Germany

Contacts

Public ContactJan Behring

Behring und Partner, Zahnärztliche Gemeinschaftspraxis

praxis@behring-und-partner.de040-2512925

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026