Prematurity and low birth weight P07
Conditions
Interventions
Group 1: 40 neonates in group A will be managed by Caffeine citrate 20 mg/kg intravenously as the initial dose on the 1st day of life, and then 5 mg/kg intravenously daily as the maintenance dose for
Sponsors
Ministry of Higher Education, Research Committee
Eligibility
Sex/Gender
All
Age
1 Days to 8 Days
Inclusion criteria
Inclusion criteria: Preterm neonates who fulfill both of the following criteria will be enrolled in the study. • Gestational age =34weeks. • Weight less than 1500g.
Exclusion criteria
Exclusion criteria: Neonates have visible or physically detected malformation, birth asphyxia, and parent who declined consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1- The risk of apnea: Apnea is defined as a cessation of breathing for 20 seconds or longer, or a shorter pause accompanied by bradycardia (heart rate less than 100 beats per minute for 4 seconds or longer), or low blood oxygen saturation (SpO2 less than 80% for 4 second or longer) in infants less than 37 weeks of gestation. The apnea will be diagnosed by a Cardio-respiratory Monitor. Persistent of apnea attacks in preterm neonates with no other obvious causes or despite the correction of secondary causes is accepted as apnea of prematurity. The risk of apnea a group would be calculated from the number of preterm neonates with newly diagnosed apnea during 10 days of intervention divided by the number of total preterm neonates of the same group and date. 2- The total duration of apnea attacks will be demonstrated in days. The duration of apnea attacks will be calculated from the starting day up to the ending day of apnea. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1- The duration of oxygen therapy in days. Oxygen treatment is indicated when oxygen saturation falls below the target level (85% for neonates equal or more than 28 weeks gestation and 91% for neonates less than 28 weeks gestation), and the development of apnea, or cyanosis. 2- The duration of mechanical ventilation is days. The indications for initiation of mechanical ventilation are: PaO2 60 mmHg, intractable or recurrent apnea, gasping or poor respiration, O2 saturation 60 mmHg) despite CPAP pressure of 7–8 cm H2O and FiO2 of 0.8 or recurrent episodes of apnea. 3- The proportion of neonates who need mechanical ventilation. 4- The relative risks of neonatal irritability (excessive crying for more than 4hr), tachycardia (heart rate more than 180beats/minute), seizure (involuntary movements with disturbed conscious) and death during the intervention period. All are possible side effects of Caffeine citrate. | — |
Countries
Afghanistan
Contacts
Public ContactMansoor Aslamzai
Kabul University of Medical science
Outcome results
None listed