Heparin- and Protamine: Differentiation with established and new viscoelastic tests

Heparin- and Protamine: Differentiation with established and new viscoelastic tests - HepProDiff

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00020386

Enrollment

Registered

2020-01-09

Start date

2021-01-13

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anticoagulation with heparin and its antagonisation with protamine

Interventions

Group 1: Cardiac surgery patients with bypass operation with or without valve reconstruction. Before starting surgery, directly after heparin application, directly before protamine application and aft

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Cardiac surgery (Bypass with or without valve reconstruction) 2. Patient Agreement

Exclusion criteria

Exclusion criteria: 1. Age <18 years 2. Multiple valve reconstruction 3. Planned intraoperative Hypothermia (<34°C) 4. Preoperative Heparin 5. myelodysplastic syndrome 6. Refusal of patient

Design outcomes

Primary

Measure	Time frame
Difference (prolongation of clotting time) in RVV-test between heparin and protamine	—

Secondary

Measure	Time frame
Accuracy of decision tree for the differentiation of heparin and protamine.	—

Countries

Germany

Contacts

Public ContactPhilipp Groene

Klinik für AnästhesiologieKlinikum der Universität MünchenLMU München

philipp.groene@med.uni-muenchen.de0894400131511219

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026