F32
Conditions
Interventions
Group 1: Three resting-state electroencephalograms of patients with major depression disorder, who undergo rTMS therapy are recorded. The first recording is conducted before the first rTMS session, an
Sponsors
Universitätsklinik für Psychiatrie und Psychotherapie Bern
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - Meet diagnostic criteria of major depressive disorder - Prescribed rTMS treatment by a psychiatrist (or standard therapy for the control group) - Age: 18-65 - Ability to give informed consent as documented by signature
Exclusion criteria
Exclusion criteria: - Contraindication of rTMS treatment (epilepsy, abnormal EEG signature) - Previous history of neurological disorders (neurodegenerative disorder, dementia, and stroke). - Comorbidity of psychotic disorders (Schizophrenia, Schizoaffective disorder, bipolar disorder) - Pregnancy (excluded from rTMS treatment itself, as little evidence of its safety for pregnant woman is available) - Current non-prescribed psychoactive drugs - Drug abuse - Inability to consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is the investigation of an electrophysiological biomarker of whether theta- and alpha-band EEG activity can predict outcome of rTMS treatment for MDD. More specifically, we focus on following electrophysiological measures: 1) Pre-treatment baseline EEG activity 2) Mid-treatment EEG activity 3) Changes of EEG activity through rTMS treatment (Post-treatment – pre-treatment) | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is an exploratory investigation of the association between severity of major depression symptoms and electrophysiological measures. | — |
Countries
Switzerland
Contacts
Public ContactMatthias Grieder
Universitätsklinik für Psychiatrie und Psychotherapie Bern
Outcome results
None listed