E66
Conditions
Interventions
Group 1: 15 Study participants, aged between 18 and 65 years, and BMI (kg/m2) > 35 (= grade 2 obesity, according to the accepted thresholds for obesity by the World Health Organization),
- receiving
Sponsors
Zentralinstitut für Seelische Gesundheit Mannheim
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: For all study participants - age between 18 and 65 years, - the capacity to give informed consent and to handle the questionnaires - written informed consent For patients: - BMI (kg/m2) > 35 (= grade 2 obesity) according to the ICD-10 - waist circumference < 160 cm (limited by scanner diameter)
Exclusion criteria
Exclusion criteria: -withdrawal of informed consent - history or current diagnosis of any psychiatric disorder, (with the exception of nicotine addiction) that needed to be treated pharmacologically in the last 12 months - current cognitive behavioral therapy - current use of illicit drugs - current suicidal ideation - history of brain injury or severe neurological disorder - current instable somatic disorder - current intake (last 4 months) of any centrally acting psychoactive or anti-obesity medications (i.e. sedatives, antipsychotics, including long-acting injectable antipsychotics, antidepressants, opioid analgesics as well as DPP (dipeptidyl peptidose IV) inhibitors and GLP (Glucagon-like peptide)-1 antagonists, - all participants with a history of surgical interventions in the gastrointestinal system -all participants requiring permanent medical monitoring or requiring medical interventions during the study period - contraindications to fMRI scanning (e.g. metal implants), - pregnant or breast-feeding females
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our study was aimed at detecting alterations of mesolimbic response to food-associated visual cues, both 8 as well as 24 weeks after bariatric surgery (first arm: Roux en Y bypass, second arm sleeve gastrectomy) | — |
Secondary
| Measure | Time frame |
|---|---|
| In addition, our study was aimed at identifying alterations of appetite regulating hormones both 8 as well as 24 weeks after bariatric surgery (first arm: Roux en Y bypass, second arm sleeve gastrectomy). | — |
Countries
Germany
Contacts
Public ContactMalte Bumb
Zentralinstitut für Seelische GEsundheit
Outcome results
None listed