C00-C97
Conditions
Interventions
Group 1: Examination of saliva with two different carrier media (in comparison to plasma) for patient-specific tumor mutations at initial diagnosis or relapse.
Saliva (on two different carrier media)
Sponsors
Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients: - tumor activity - known tumor mutation - presence of blood plasma and saliva in the Freiburg Biobank healthy subjects: - minimum 18 years old - ready to donate two saliva samples and to have peripheral blood drawn (36ml)
Exclusion criteria
Exclusion criteria: Healthy subjects: - pre-existing chronic disease, especially cancer or rheumatological diseases - pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Detection rate of ctDNA from saliva 2. Correlation of ctDNA levels between saliva and blood plasma | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Detection rate of ctDNA from saliva collected with a buccals swab or with NaCl solution | — |
Countries
Germany
Contacts
Public ContactEliza Lauer
Universitätsklinikum Freiburg, Klinik für Innere Medizin I, Zentrum für translationale Zellforschung
Outcome results
None listed