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A prospective, randomized clinical trial in split mouth design analyzing the influence of an autologous fibrin matrix (PRF) on wound healing and bone regeneration after osteotomy of displaced and retained third molars

A prospective, randomized clinical trial in split mouth design analyzing the influence of an autologous fibrin matrix (PRF) on wound healing and bone regeneration after osteotomy of displaced and retained third molars - 3rd Molar PRF

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00019229
Enrollment
60
Registered
2020-01-02
Start date
2022-01-04
Completion date
Unknown
Last updated
2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Regeneration of extraction sockets K08.1

Interventions

Group 1: Treatment Group 1 - PRF high, Socket Preservation after tooth extraction with PRF prepared at high g-force Group 2: Treatment Group 2 - PRF medium, Socket Preservation after tooth extraction

Sponsors

Universitätsklinikum der Goethe-Universität Frankfurt am Main Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients in need of osteotomy of at least two third molars (at least 1 tooth on each side); Patients with informed consent (under age patients with parents approval); Patients at an age of at least 16 years

Exclusion criteria

Exclusion criteria: Patients younger than 16 years; Patients with contraindication for surgery; Patients allergic to necessary medication and/or medical devices; Patients with chronic medication possibly influencing pain perception and/or inflammation and/or wound healing ; Immunocompromised persons; Patients without informed consent; Pregnant or breast feeding women

Design outcomes

Primary

MeasureTime frame
- Pain (VAS) - Swelling according to Gabka+Matsumara, measured between 5 reference points—

Secondary

MeasureTime frame
- wound healing and morbidity - trismus (maximal mouth opening) - post-surgery complications - photo documentation of wound healing—

Countries

Germany

Contacts

Public ContactShahram Ghanaati

Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, Universitätsklinikum der Goethe-Universität, Frankfurt am Main

s.ghanaati@med.uni-frankfurt.de+49-69-6301-4492

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026