Influence of one-lung-ventilation on the integrity of cerebrovascular autoregulation

Influence of one-lung-ventilation on the integrity of cerebrovascular autoregulation - ELVeCA

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00019204

Enrollment

101

Registered

2019-11-18

Start date

2019-11-04

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral autoregulation

Interventions

Group 1: Cerebral oxygen saturation can be measured non-invasively using near-infrared spectroscopy (NIRS). The NIRS sensors will be positioned according to the manufacturer’s instructions on the righ

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients meeting the following criteria are included in the study: - Age = 18 years - Ability to consent - RAMIE (robotic assisted minimally invasive esophagectomy, DaVinci)

Exclusion criteria

Exclusion criteria: Patients who fulfill only one of the following criteria are not included in the study: - Pregnancy and breastfeeding - missing temporal ultrasound window

Design outcomes

Primary

Measure	Time frame
The primary outcome is if and to what extent an impairment of the cerebral autoregulation occurs during one lung ventilation as part of the robotic assisted minimal invasive esophagectomy (RAMIE, DaVinci®). The data will be gathered during the surgery.	—

Secondary

Measure	Time frame
Secondary outcomes are: 1) Comparability of the calculation of cerebrovascular autoregulation capacity using NIRS and the gold standard TCD 2) Characteristic of the time course in the integrity of the cerebrovascular autoregulation 3) Functional observation of the relationship between the cerebrovascular autoregulatory capacity and the end-expiratory and arterial CO2 partial pressure respectively 4) Measurement of changes in cerebral oxygen saturation during one lung ventilation 5) Identification of critical surgical moments, which cause a disruption of autoregulatory capacity or cerebral oxygen saturation / homeostasis and should be subject to special anesthesiological observation in the future 6) Changes in cerebral blood flow velocity	—

Measure

Time frame

Secondary outcomes are: 1) Comparability of the calculation of cerebrovascular autoregulation capacity using NIRS and the gold standard TCD 2) Characteristic of the time course in the integrity of the cerebrovascular autoregulation 3) Functional observation of the relationship between the cerebrovascular autoregulatory capacity and the end-expiratory and arterial CO2 partial pressure respectively 4) Measurement of changes in cerebral oxygen saturation during one lung ventilation 5) Identification of critical surgical moments, which cause a disruption of autoregulatory capacity or cerebral oxygen saturation / homeostasis and should be subject to special anesthesiological observation in the future 6) Changes in cerebral blood flow velocity

—

Countries

Germany

Contacts

Public ContactSusanne Fischer

Klinisches Studienzentrum, Klinik für Anästhesiologie, Universitätsmedizin Mainz

susanne.fischer@unimedizin-mainz.de+496131177175

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026