Microbiota and proteome in norovirus gastroenteritis

Microbiota and proteome in norovirus gastroenteritis - PRESENt

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00019089

Enrollment

500

Registered

2020-03-26

Start date

2020-04-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A08 A09

Interventions

Group 1: Collection of stool and saliva samples over a period of 90 days (collection on days 1, 7, 14, 28 and 90) in patients with Norovirus-associated gastroenteritis. Additional processing of patien

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Male and female patients at the age of =18 - Patients with gastroenteritis - Written consent of the patient after information has been provided

Exclusion criteria

Exclusion criteria: - Patients who do not have diarrheal gastroenteritis (defined as 3 or more loose or liquid stools per day) - diseases that do not allow the person concerned to assess the nature and extent of the clinical trial and its possible consequences - Indications that the patient is unlikely to comply with the protocol (e.g., lack of cooperation)

Design outcomes

Primary

Measure	Time frame
Identification of "key"-bacteria and "key"-proteins associated with Norovirus-induced gastroenteritis	—

Secondary

Measure	Time frame
1. Analysis of the dynamics within the intestinal microbiome and proteome in the natural course of norovirus-associated gastroenteritis with special focus on the identification of potential biomarkers 2. analysis of the composition of the proteome of intestinal exosomes with regard to specific patterns associated with norovirus-associated gastroenteritis 3. analysis of the composition of the intestinal microbiome for specific patterns associated with norovirus-associated gastroenteritis. 4. to determine the correlations between clinical, external and lifestyle factors with the risk of norovirus-associated gastroenteritis 5. to determine the correlations between clinical, external and lifestyle factors with the course of norovirus-associated gastroenteritis 6. analysis of FUT2 genotype and correlation with norovirus-associated gastroenteritis	—

Measure

Time frame

1. Analysis of the dynamics within the intestinal microbiome and proteome in the natural course of norovirus-associated gastroenteritis with special focus on the identification of potential biomarkers 2. analysis of the composition of the proteome of intestinal exosomes with regard to specific patterns associated with norovirus-associated gastroenteritis 3. analysis of the composition of the intestinal microbiome for specific patterns associated with norovirus-associated gastroenteritis. 4. to determine the correlations between clinical, external and lifestyle factors with the risk of norovirus-associated gastroenteritis 5. to determine the correlations between clinical, external and lifestyle factors with the course of norovirus-associated gastroenteritis 6. analysis of FUT2 genotype and correlation with norovirus-associated gastroenteritis

—

Countries

Germany

Contacts

Public ContactBenjamin Heidrich

Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover

Heidrich.benjamin@mh-hannover.de017615322489

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026