Dopaminergic mechanisms of reinforcement learning and working memory deficits in schizophrenia patients

Dopaminergic mechanisms of reinforcement learning and working memory deficits in schizophrenia patients - DoReMe

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00019079

Enrollment

Registered

2019-11-28

Start date

2019-10-29

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F20

Interventions

Group 1: Patients with schizophrenia will be investigated with FDOPA PET and fMRI before and four weeks after treatment with antipsychotic drug Group 2: Healthy controls will be investigated at baseli

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: schizophrenia

Exclusion criteria

Exclusion criteria: contraindication for MRI and/or FDOPA PET

Design outcomes

Primary

Measure	Time frame
FDOPA-PET: Dopamine synthesis capacity in striatum, fMRI: activation in frontostriatal Areas during reward learning and in fronto-parietal Areas durinh working memory	—

Secondary

Measure	Time frame
psychopathology (PANSS, BNSS, PDI, CDS), cognition (BACS), functioning (GAF, PSP)	—

Countries

Germany

Contacts

Public ContactLara Wieland

Charité-Universitätsmedizin Berlin

lara.wieland@charite.de+49 30 450 517379

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026