Determination of microRNA biomarkers from blood for the pre- and post-treatment monitoring of non-small cell lung cancer (NSCLC)

Determination of microRNA biomarkers from blood for the pre- and post-treatment monitoring of non-small cell lung cancer (NSCLC) - LuMiR-Studie

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00018992

Enrollment

160

Registered

2019-11-27

Start date

2020-09-22

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C34 R91 J44

Interventions

Group 1: • patients with diagnosed lung carcinoma (NSCLC) stage I (T1 / T2 / T3-N0-M0). Several blood samples will be taken throughout the study periods (baseline sample and up to 7 follow-up samples)

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Inclusion criteria

Inclusion criteria: • Male or female patient 50-80 years • Patients suspicious to lung carcinoma (NSCLC) stage I and II or patients by whome the malignancy was excluded after resection (control group 2, for example benign lung disease) or patients with a lung disease (control group 3, eg COPD patients) • Sufficient knowledge of German and the willingness to participate in the study

Exclusion criteria

Exclusion criteria: • known active infectious diseases (HIV, HCV, HBV) • Neoadjuvant therapy or invasive diagnostics • cancer in the last 5 years (except locally treated skin carcinoma - not malignant melanoma or prostate cancer)

Design outcomes

Primary

Measure	Time frame
Longitudinal analysis of microRNA biomarkers before and after resection of a curatively targeted localized non-small cell lung carcinoma (T1 / T2 / T3-N0-M0)	—

Secondary

Measure	Time frame
Pre- and post-operation comparison of miRNA profiles for the diagnosis of minimal residual disease.	—

Countries

Germany

Contacts

Public ContactPeter Feindt

Clemenshospital

Info.clemenshospital@alexianer.de0049 251 976 0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026