N14.1
Conditions
Interventions
Group 1: Healthy volunteers serve as a comparison collective with which, in particular, the reproducibility of the fMRI measurement (retest reliability) is examined.
Group 2: Patients who are consider
Sponsors
Universitätsklinikum Tübingen, Radiologische Klinik, Diagnostische & Interventionelle Radiologie
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Perform kidney scintigraphy for a clinical indication (relevant risk of developing renal damage due to planned potential nephrotoxic therapy (e.g., radiotherapy)), • Age =18 years, • Written consent of the patient.
Exclusion criteria
Exclusion criteria: Pregnant / lactating women, Presence of non-MRI-compatible implants or any type of metal in and on the body, (e.g., pacemakers, artificial heart valves, metal prosthesis, implanted magnetic metal parts, spiral, etc.), patients who report hearing disorder or increased sensitivity to loud noises, patients with limited temperature sensation and / or increased sensitivity to warming of the body, patients who suffer from claustrophobia, obesity >150 kg body weight, patients who do not want to be informed about incidental findings, limited ability to consent of the patient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recording of potential morphological and functional changes of the renal parenchyma by means of fMRI and the subsequent correlation of the MR data with the reference standard (various laboratory parameters, kidney scintigraphy, if necessary follow-up). | — |
Secondary
| Measure | Time frame |
|---|---|
| Development of a score using MRI, laboratory parameters and scintigraphy to predict the likelihood of later onset of nephropathy (predictive value). | — |
Countries
Germany
Contacts
Public ContactFerdinand Seith
Universitätsklinikum Tübingen, Radiologische Klinik, Diagnostische & Interventionelle Radiologie
Outcome results
None listed