Platelet function Thrombelastometry
Conditions
Interventions
Group 1: Administration of mannitol 20% to 1g / kg body weight. Measurement of platelet function before and 30 min after the administration of mannitol. Mannitol administration is independent of the s
Sponsors
Klinik für Anästhesiologie und Intensivmedizin Medizinische Hochschule Hannover
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • Patients = 18 years, Intra-cranial procedure with the indication for the administration of mannitol (1 g per kg of body weight) given by the surgeon on the basis of the surgical site.
Exclusion criteria
Exclusion criteria: Intake of anticoagulant or antiplatelet agents without decreasing the clinical duration of the same substances (eg, ASA, Marcumar, Heparins, other NSAIDs, etc., NOACs).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC in impedance aggregometry with ADP, ASPI and TRAP (Multiplate Analyzer) | — |
Secondary
| Measure | Time frame |
|---|---|
| • Maximum Clot Firmness (MCF) in the FibTem® test • Maximum Clot Firmness (MCF) in the ExTem® test • Clotting time (CT) in ExTem® and FibTem® test • Clotformation Time (CFT) in the ExTem® and FibTem® tests • Clottingtime (CtPFA) in the PFA-100 test • International Normalized Ratio (INR) • Activated partial thromboplastin time (aPTT) • hematocrit • platelet count | — |
Countries
Germany
Contacts
Public ContactThomas Palmaers
Klinik für Anästhesiologie und Intensivmedizin Medizinische Hochschule Hannover
Outcome results
None listed