In a first phase of the study only healthy participants are studied.
Conditions
Interventions
Group 1: Healthy participants are studied during a fear conditioning paradigm (Acquisition, Extinction, Re-
Instatement, Extinction Recall). After extinction and before proceeding with re-instatement,
Sponsors
Universität des Saarlandes, Abteilung für Klinische Psychologie und Psychotherapie
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: - Healthy volunteers - normal weight (BMI between 18.5 and 26) - For women: regular usage of hormonal contraceptives
Exclusion criteria
Exclusion criteria: - Acute or chronic medical/psychiatric problems - Diabetes - Previous traumatic experience or acute depressive feelings - Prolonged intake of medication (exception: contraceptives) - Participation in pharmacological studies in the last 4 weeks - Regular consum of nicotine, alcohol or drugs - Tinnitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Differences in fear extinction, reinstatement and extinction recall between groups (glucose vs. placebo) - Paradigm used: Differential Fear Conditioning (Acquisition, Extinction, Reinstatement, extinction recall) - Variables of interest: Electrodermal response (EDA), startle reaction (EMG of the orbicularis oculi muscle), heart rate (ECG), subjective ratings of the stimulus (contingency awareness, fear, expectancy). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Heart rate variability (HRV) and electrodermal response (EDA) assessed during resting state at different points of the experiment - Questionnaires and subjective ratings (STAI-S, arousal, stress, activation, anxiety and unpleasantness of electroshock) assessed throughout the experiment - Blood glucose after drink consumption, measured with a blood glucose-monitoring device. | — |
Countries
Germany
Contacts
Public ContactAlexander Hauck
Universität des Saarlandes, Abteilung für Klinische Psychologie und Psychotherapie
Outcome results
None listed