M17.1 F43.9
Conditions
Interventions
Group 1: osteoarthritis patients prior to knee TEP surgery
Group 2: healthy control Group, no OA, no Rheuma, no injuries
Sponsors
Dr. Rolf M. Schwiete Forschungsbereich für Osteoarthrose, Universitätsklinikum Frankfurt, Klinik für Orthopädie (Friedrichsheim)
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: • Knee OA patients pre-/post-knee TEP, females and males, between 18 and 85 y. • healthy controls , no OA, no Rheuma, no injuries, females and males, between 18 and 85 y.
Exclusion criteria
Exclusion criteria: General: injuries oft he lower limbs, no written consent Gait analysis: BMI = 30 • former endoprothetic surgeries of the hip or ankle joint • ASA-classification > 2 • any surgery of the lower limbs 6 months before • rheumatoide arthritis • neurological disorders (z.B. Morbus Parkinson, stroke with paralysis, Muskeldystrophie, Epilepsy, Multiple Sklerosis, Paraneoplastic neurological Syndrom (PNS), Tremor, Alzheimer, Chorea, Huntington, Polio, Zerebralparesis), injuries of the lower limbs, no written consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The overall aim of this study is the analysis of the SNS-PNS (im)balance in OA patients and the correlation of these data with clinical symptoms and in vitro cellular responses of different joint tissues, which have been removed during knee replacement surgery. A possible SNS>PNS imbalance will be analyzed and correlated with clinical parameters (imaging data, pain, knee instability, gait pattern). | — |
Countries
Germany
Contacts
Public ContactAntje Steidl
Dr. Rolf M. Schwiete Forschungsbereich für Osteoarthrose, Universitätsklinikum Frankfurt, Klinik für Orthopädie (Friedrichsheim)
Outcome results
None listed